Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease
N Alkhouri, R De Vito, A Alisi, L Yerian, R Lopez… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Pediatric non-alcoholic fatty liver disease (NAFLD) may present
with a distinct histopathological pattern characterized by the presence of predominant portal-
based injury and portal inflammation (PI). We aimed at developing a new grading score for
pediatric NAFLD to be used in clinical trials that takes into account the presence of PI and
the weight of histological features. METHODS: Our training set consisted of 203 children with
biopsy-proven NAFLD. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on …
with a distinct histopathological pattern characterized by the presence of predominant portal-
based injury and portal inflammation (PI). We aimed at developing a new grading score for
pediatric NAFLD to be used in clinical trials that takes into account the presence of PI and
the weight of histological features. METHODS: Our training set consisted of 203 children with
biopsy-proven NAFLD. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on …