[HTML][HTML] Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance
JO Holloszy - The American journal of clinical nutrition, 2009 - Elsevier
Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant
offspring of patients with diabetes have≈ 30% less mitochondria in their skeletal muscles
than age-matched healthy controls. It has been hypothesized that this “deficiency” of
mitochondria mediates insulin resistance by impairing the ability of muscle to oxidize fatty
acids (FAs). However, a 30% decrease in mitochondria should not impair the ability of
muscle to oxidize FAs because the capacity of muscle to oxidize substrate is far in excess of …
offspring of patients with diabetes have≈ 30% less mitochondria in their skeletal muscles
than age-matched healthy controls. It has been hypothesized that this “deficiency” of
mitochondria mediates insulin resistance by impairing the ability of muscle to oxidize fatty
acids (FAs). However, a 30% decrease in mitochondria should not impair the ability of
muscle to oxidize FAs because the capacity of muscle to oxidize substrate is far in excess of …