Effect of impaired glucose tolerance and type II diabetes on resting metabolic rate and thermic response to a glucose meal in obese women

KS Nair, J Webster, JS Garrow - Metabolism, 1986 - Elsevier
KS Nair, J Webster, JS Garrow
Metabolism, 1986Elsevier
We examined the hypothesis that patients with impaired glucose tolerance or type II
diabetes mellitus have reduced glucose-induced thermogenesis and that this perpetuates
obesity in them by reducing energy expenditure. The thermic response after a 75-g glucose
meal for 150 minutes was significantly lower in five obese women with diabetes (7.18±1.8
kcal) and five other obese women with impaired glucose tolerance (6.4±0.8 kcal) than in five
obese women with normal glucose tolerance (16.7±2.4 kcal) and five lean healthy control …
We examined the hypothesis that patients with impaired glucose tolerance or type II diabetes mellitus have reduced glucose-induced thermogenesis and that this perpetuates obesity in them by reducing energy expenditure. The thermic response after a 75-g glucose meal for 150 minutes was significantly lower in five obese women with diabetes (7.18±1.8 kcal) and five other obese women with impaired glucose tolerance (6.4±0.8 kcal) than in five obese women with normal glucose tolerance (16.7±2.4 kcal) and five lean healthy control subjects (14.0±2.2 kcal, P< 0.05). However, obese women with diabetes or impaired glucose tolerance had a significantly higher resting metabolic rate (RMR)(307.0±9.7 mL O 2/min) than predicted for them on the basis of their age, body weight, and total body potassium (274.8±8.0 mL O 2/min, p< 0.01). The predicted RMR in obese women with normal glucose tolerance test (GTT)(286.0±5.0 mL O 2/min) was not different from their observed RMR (272.0±6.0). Thus the total energy expenditure during the meal of obese women with diabetes (254±32 kcal 150 min) and obese women with impaired glucose tolerance (221±5 kcal 150 min) was higher than that of obese women with normal glucose tolerance (201±9 kcal 150 min). All three obese groups had a higher total energy expenditure than the lean group (158±4 kcal 150 min, P< 0.001). It is concluded that even though in patients with type II diabetes or impaired glucose tolerance there is a reduction in the increment in metabolic rate after a glucose meal, they also have elevated RMR and total energy expenditure. Obese patients with diabetes and impaired glucose tolerance require more kcal/LBM (lean body mass) to maintain their body weight than the control subjects.
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