Regulatory T cells versus Th17: Differentiation of Th17 versus treg, are they mutually exclusive?
SG Zheng - IL-17, IL-22 and Their Producing Cells: Role in …, 2013 - Springer
IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity, 2013•Springer
Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg)
cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell
differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending
upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell
differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17
cells in the inflammatory milieu. This chapter discusses the updates of these cell …
cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell
differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending
upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell
differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17
cells in the inflammatory milieu. This chapter discusses the updates of these cell …
Abstract
Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.
Springer