PRDM5 is silenced in human cancers and has growth suppressive activities
Q Deng, S Huang - Oncogene, 2004 - nature.com
Q Deng, S Huang
Oncogene, 2004•nature.comSeveral genes that contain the PR (PRDI-BF1 and RIZ) domain have been linked with
human cancers. We describe here a new PR-domain-containing gene designated as
PRDM5 (PFM2). A PRDM5 cDNA was isolated based on its homology to the PR domain of
RIZ1 (PRDM2). The gene encodes an open reading frame of 630 amino acids and contains
a PR domain in the NH-terminal region followed by 16 zinc finger motifs. Radiation hybrid
analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor …
human cancers. We describe here a new PR-domain-containing gene designated as
PRDM5 (PFM2). A PRDM5 cDNA was isolated based on its homology to the PR domain of
RIZ1 (PRDM2). The gene encodes an open reading frame of 630 amino acids and contains
a PR domain in the NH-terminal region followed by 16 zinc finger motifs. Radiation hybrid
analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor …
Abstract
Several genes that contain the PR (PRDI-BF1 and RIZ) domain have been linked with human cancers. We describe here a new PR-domain-containing gene designated as PRDM5 (PFM2). A PRDM5 cDNA was isolated based on its homology to the PR domain of RIZ1 (PRDM2). The gene encodes an open reading frame of 630 amino acids and contains a PR domain in the NH-terminal region followed by 16 zinc finger motifs. Radiation hybrid analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor suppressor genes for breast, ovarian, liver, lung, colon, and other cancers. The gene has a CpG island promoter and is silenced in human breast, ovarian, and liver cancers. A recombinant adenovirus expressing PRDM5 caused G2/M arrest and apoptosis upon infection of tumor cells. These results suggest that inactivation of PRDM5 may play a role in carcinogenesis.
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