CEP152 is a genome maintenance protein disrupted in Seckel syndrome
Nature genetics, 2011•nature.com
Functional impairment of DNA damage response pathways leads to increased genomic
instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic
integrity and cellular response to DNA damage. Using homozygosity mapping and exome
sequencing, we identified CEP152 mutations in Seckel syndrome and showed that impaired
CEP152 function leads to accumulation of genomic defects resulting from replicative stress
through enhanced activation of ATM signaling and increased H2AX phosphorylation.
instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic
integrity and cellular response to DNA damage. Using homozygosity mapping and exome
sequencing, we identified CEP152 mutations in Seckel syndrome and showed that impaired
CEP152 function leads to accumulation of genomic defects resulting from replicative stress
through enhanced activation of ATM signaling and increased H2AX phosphorylation.
Abstract
Functional impairment of DNA damage response pathways leads to increased genomic instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic integrity and cellular response to DNA damage. Using homozygosity mapping and exome sequencing, we identified CEP152 mutations in Seckel syndrome and showed that impaired CEP152 function leads to accumulation of genomic defects resulting from replicative stress through enhanced activation of ATM signaling and increased H2AX phosphorylation.
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