[HTML][HTML] Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway
Y Fei, L Xiao, T Doetschman, DJ Coffin… - Journal of Biological …, 2011 - ASBMB
Fibroblast growth factor 2 (FGF2) positively modulates osteoblast differentiation and bone
formation. However, the mechanism (s) is not fully understood. Because the Wnt canonical
pathway is important for bone homeostasis, this study focuses on modulation of Wnt/β-
catenin signaling using Fgf2−/− mice (FGF2 all isoforms ablated), both in the absence of
endogenous FGF2 and in the presence of exogenous FGF2. This study demonstrates a role
of endogenous FGF2 in bone formation through Wnt signaling. Specifically, mRNA …
formation. However, the mechanism (s) is not fully understood. Because the Wnt canonical
pathway is important for bone homeostasis, this study focuses on modulation of Wnt/β-
catenin signaling using Fgf2−/− mice (FGF2 all isoforms ablated), both in the absence of
endogenous FGF2 and in the presence of exogenous FGF2. This study demonstrates a role
of endogenous FGF2 in bone formation through Wnt signaling. Specifically, mRNA …