Human dendritic cell subsets

M Collin, N McGovern, M Haniffa - Immunology, 2013 - Wiley Online Library
Immunology, 2013Wiley Online Library
Dendritic cells are highly adapted to their role of presenting antigen and directing immune
responses. Developmental studies indicate that DCs originate independently from
monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets
of DCs have intrinsic differences that lead to functional specialisation in the generation of
immunity. Comparative studies are now allowing many of these properties to be more fully
understood in the context of human immunology.
Summary
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.
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