[HTML][HTML] Interactions between Spc2p and Other Components of the Endoplasmic Reticulum Translocation Sites of the YeastSaccharomyces cerevisiae

W Antonin, HA Meyer, E Hartmann - Journal of Biological Chemistry, 2000 - ASBMB
In yeast, the endoplasmic reticulum membrane proteins Sec11p and Spc3p are essential for
the cleavage of signal peptides of nascent polypeptide chains during their passage through
translocation sites. Genetic and biochemical experiments demonstrate that Sec11p and
Spc3p are tightly associated with two other proteins, Spc1p and Spc2p, whose functions are
largely unknown. Using anti-Spc2p antibodies, we show here that this heterotetrameric
complex associates with Sbh1p and Sbh2p, the β-subunits of the Sec61p complex and the …