An α5β1 integrin inhibitor attenuates glioma growth

K Färber, M Synowitz, G Zahn, D Vossmeyer… - Molecular and Cellular …, 2008 - Elsevier
Integrins are heterodimeric transmembrane proteins, which mediate cell–cell and cell–
extracellular matrix (ECM) interaction. We show, that an inhibitor of alpha5 beta1 integrin
(α5β1), JSM6427, attenuated glioma growth and decreased the density of microglia at the
tumor border. 21 days after glioma cell injection into an experimental mouse model, the
tumor volume was significantly smaller after treating animals for 14 days with JSM6427 as
compared to controls. We could demonstrate the expression of integrin α5β1 on both …