Despite of the claim that maternal leukemia inhibitory factor (LIF)–a member of interleukin 6
(IL6) family of cytokines–plays indispensable roles for murine embryo implantation, these
roles remain undefined in humans because the potency of LIF on implantation appears to
vary among individuals. Here, we showed that the contribution of LIF for murine implantation
was dependent on the strains of mice (ICR, C57BL/6J (B6), ddY, BALB/c, DBA/2Cr and MF1
strains). Inhibition of LIF during the implantation period caused severe disruption of embryo …