Resolution of infection and inflammation is governed by innate immune cells. The resolvin
family of n-3 mediators produced by resolving exudates stimulates clearance of neutrophils
and attenuates pro-inflammatory signals. Using metabololipidomics, endogenous resolvin
D3 (RvD3) was identified in self-resolving exudates during active E. coli infection. Through a
new, independent synthetic route for RvD3, we matched endogenous and synthetic RvD3
and determined that RvD3 (ng doses) potently reduced the resolution interval (R i) by~ 4.5 h …