The role of aspirin-triggered lipoxins in the mechanism of action of aspirin
DW Gilroy - Prostaglandins, leukotrienes and essential fatty acids, 2005 - Elsevier
Few drugs have treated so many diseases, provided us with so much understanding of their
pathogenesis, and tested our scientific creativity over the last 100 years as much as aspirin.
Originally, the beneficial effects of aspirin were shown to stem from its inhibition of
cyclooxygenase (COX 2)-derived prostanoids, fatty acid metabolites that modulate host
defense and regulate the cardiovascular system. However, the inhibition of COX 2 enzyme
activity and prostaglandin synthesis has never fully explained aspirin's repertoire of anti …
pathogenesis, and tested our scientific creativity over the last 100 years as much as aspirin.
Originally, the beneficial effects of aspirin were shown to stem from its inhibition of
cyclooxygenase (COX 2)-derived prostanoids, fatty acid metabolites that modulate host
defense and regulate the cardiovascular system. However, the inhibition of COX 2 enzyme
activity and prostaglandin synthesis has never fully explained aspirin's repertoire of anti …