The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

SK Hanks, AM Quinn, T Hunter - Science, 1988 - science.org
Science, 1988science.org
In recent years, members of the protein kinase family have been discovered at an
accelerated pace. Most were first described, not through the traditional biochemical
approach of protein purification and enzyme assay, but as putative protein kinase amino
acid sequences deduced from the nucleotide sequences of molecularly cloned genes or
complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic
domains can serve as a useful first step in the functional characterization of these newly …
In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino acid sequences deduced from the nucleotide sequences of molecularly cloned genes or complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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