[PDF][PDF] High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma

I Bongarzone, MA Pierotti, N Monzini, P Mondellini… - Oncogene, 1989 - researchgate.net
Activated oncogenes have been detected in a variety of fresh solid tumours by transfection
on NIH3T3 cells (Bishop, 1987) and in most cases the transforming gene belongs to the
RAS gene family (Barbacid, 1987). Recently, we detected by transfection, an oncogene in 5
of 20 papillary thyroid carcinomas (Fusco et al., 1987). We designated the oncogene PTC
(from papillary thyroid carcinoma) and we have assigned it to the q arm of chromosome 10
(Donghi et al., 1989). The transforming activity of PTC has been recently determined by …