[HTML][HTML] Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand
Y Kanaoka, A Maekawa, KF Austen - Journal of Biological Chemistry, 2013 - ASBMB
The cysteinyl leukotrienes (cys-LTs), leukotriene C 4 (LTC 4), a conjugation product of
glutathione and eicosatetraenoic acid, and its metabolites, LTD 4 and LTE 4, are lipid
mediators of smooth muscle constriction and inflammation in asthma. LTD 4 is the most
potent ligand for the type 1 cys-LT receptor (CysLT 1 R), and LTC 4 and LTD 4 have similar
lesser potency for CysLT 2 R, whereas LTE 4 has little potency for either receptor.
Cysltr1/Cysltr2−/− mice, lacking the two defined receptors, exhibited a comparable dose …
glutathione and eicosatetraenoic acid, and its metabolites, LTD 4 and LTE 4, are lipid
mediators of smooth muscle constriction and inflammation in asthma. LTD 4 is the most
potent ligand for the type 1 cys-LT receptor (CysLT 1 R), and LTC 4 and LTD 4 have similar
lesser potency for CysLT 2 R, whereas LTE 4 has little potency for either receptor.
Cysltr1/Cysltr2−/− mice, lacking the two defined receptors, exhibited a comparable dose …