[HTML][HTML] Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation

M Fumagalli, S Daniele, D Lecca, PR Lee… - Journal of Biological …, 2011 - ASBMB
The developing and mature central nervous system contains neural precursor cells
expressing the proteoglycan NG2. Some of these cells continuously differentiate to myelin-
forming oligodendrocytes; knowledge of the destiny of NG2+ precursors would benefit from
the characterization of new key functional players. In this respect, the G protein-coupled
membrane receptor GPR17 has recently emerged as a new timer of oligodendrogliogenesis
. Here, we used purified oligodendrocyte precursor cells (OPCs) to fully define the …