[HTML][HTML] A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and …
L Luo, R Tanaka, S Kanazawa, F Lu, A Hayashi… - Journal of Diabetes and …, 2017 - Elsevier
Aims The synthetic leukotriene B 4 receptor type 2 (BLT2) agonist CAY10583 (CAY)
accelerates wound healing in diabetic mice by promoting keratinocyte migration. However,
its effects on fibroblast activity and granulation are unknown. We investigated the
mechanisms by which CAY promotes wound healing. Methods CAY was applied to wounds
on streptozotocin-induced diabetic rats, and wound closure, granulation thickness, and
epithelialization gaps were analyzed. BLT2 expression was examined by RT-PCR …
accelerates wound healing in diabetic mice by promoting keratinocyte migration. However,
its effects on fibroblast activity and granulation are unknown. We investigated the
mechanisms by which CAY promotes wound healing. Methods CAY was applied to wounds
on streptozotocin-induced diabetic rats, and wound closure, granulation thickness, and
epithelialization gaps were analyzed. BLT2 expression was examined by RT-PCR …