[HTML][HTML] Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation

K Kuniyeda, T Okuno, K Terawaki, M Miyano… - Journal of biological …, 2007 - ASBMB
Many G-protein-coupled receptors can activate more than one G-protein subfamily member.
Leukotriene B 4 receptor type 1 (BLT1) is a high affinity G-protein-coupled receptors for
leukotriene B 4 functioning in host defense, inflammation, and immunity. Previous studies
have shown that BLT1 utilizes different G-proteins (the G i family and G 16 G-proteins) in
mediating diverse cellular events and that truncation of the cytoplasmic tail of BLT1 does not
impair activation of G i and G 16 proteins. To determine responsive regions of BLT1 for G …