Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT2 receptor
V Capra, C Carnini, MR Accomazzo… - Prostaglandins & Other …, 2015 - Elsevier
We evaluated the autocrine activities of cysteinyl leukotrienes (cysteinyl-LTs) in HUVEC and
studied the signaling and the pharmacological profile of the CysLT 2 receptor (CysLT 2 R)
expressed by ECs, finally assessing the role of the CysLT 2 R in permeability alterations in a
model of isolated brain. Cysteinyl-LTs and their precursor LTA 4 contracted HUVEC and
increased permeability to macromolecules, increasing the formation of stress fibers through
the phosphorylation of myosin light-chain (MLC) following Rho and PKC activation …
studied the signaling and the pharmacological profile of the CysLT 2 receptor (CysLT 2 R)
expressed by ECs, finally assessing the role of the CysLT 2 R in permeability alterations in a
model of isolated brain. Cysteinyl-LTs and their precursor LTA 4 contracted HUVEC and
increased permeability to macromolecules, increasing the formation of stress fibers through
the phosphorylation of myosin light-chain (MLC) following Rho and PKC activation …