Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig
S Bochnowicz, DC Underwood - Prostaglandins, leukotrienes and …, 1995 - Elsevier
The iv administration of leukotriene (LT) D4 to anesthetized guinea pigs produced dose-
dependent increases in pulmonary microvascular permeability, as measured by
extravasation of Evans blue dye into the trachea, main bronchi, and small airways, with an
ED50 of approximately 0.05 μg/kg. When LTD4 was administered at 0.3 μg/kg, the resulting
plasma extravasation into all three airway sections was markedly reduced by pretreatment
with a cyclooxygenase inhibitor, meclofenamic acid (2.5 mg/kg, iv), a thromboxane (TX) …
dependent increases in pulmonary microvascular permeability, as measured by
extravasation of Evans blue dye into the trachea, main bronchi, and small airways, with an
ED50 of approximately 0.05 μg/kg. When LTD4 was administered at 0.3 μg/kg, the resulting
plasma extravasation into all three airway sections was markedly reduced by pretreatment
with a cyclooxygenase inhibitor, meclofenamic acid (2.5 mg/kg, iv), a thromboxane (TX) …
