Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine
JP Arm, SP O'Hickey, RJ Hawksworth, CY Fong… - Am Rev Respir …, 1990 - atsjournals.org
Am Rev Respir Dis, 1990•atsjournals.org
Airways responsiveness to leukotrlene (LT) c., LTD4, LTE4, histamine, and methacholine
have been studied In eight asthmatic and six normal subjects. Airways responsiveness to
each bronchoconstrictor agonist was assessed by constructing cumulative dose-response
curves, and the dose that produced a 35% decrease In specific airways conductance (PD35)
was obtained by linear Interpolation. Airways of subjects with asthma were approximately 14-
, 15-, 6-, 9-, and 219-fold more responsive to histamine, methacholine, LTC4, LTD4, and …
have been studied In eight asthmatic and six normal subjects. Airways responsiveness to
each bronchoconstrictor agonist was assessed by constructing cumulative dose-response
curves, and the dose that produced a 35% decrease In specific airways conductance (PD35)
was obtained by linear Interpolation. Airways of subjects with asthma were approximately 14-
, 15-, 6-, 9-, and 219-fold more responsive to histamine, methacholine, LTC4, LTD4, and …
Summary
Airways responsiveness to leukotrlene (LT) c., LTD4, LTE4, histamine, and methacholine have been studied In eight asthmatic and six normal subjects. Airways responsiveness to each bronchoconstrictor agonist was assessed by constructing cumulative dose-response curves, and the dose that produced a 35% decrease In specific airways conductance (PD35) was obtained by linear Interpolation. Airways of subjects with asthma were approximately 14-, 15-, 6-, 9-, and 219-fold more responsive to histamine, methacholine, LTC4, LTD4, and LTE4, respectively, than were normal subjects. Thus, there was a substantially augmented level of hyperresponslveness to LTE4
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