Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa
SJ Coles, KH Neill, LM Reid, KF Austen, Y Nii… - Prostaglandins, 1983 - Elsevier
The effects of leukotrienes C 4 (LTC 4) and D 4 (LTD 4) on the secretion by human bronchial
mucosa of [14 C] glucosamine-labeled, trichloro-acetic acid/phosphotungstic acid-
precipitable glycoprotein and lysozyme were evaluated in vitro. LTC 4 and LTD 4, in the
concentration range of 0.16 to 1600 nM, induced a dose-related increase in the release of
radiolabeled glycoprotein, but not of lysozyme. This secretagogue effect was selective for
high molecular weight glycoproteins of about 2–5× 10 6 daltons, and the median effective …
mucosa of [14 C] glucosamine-labeled, trichloro-acetic acid/phosphotungstic acid-
precipitable glycoprotein and lysozyme were evaluated in vitro. LTC 4 and LTD 4, in the
concentration range of 0.16 to 1600 nM, induced a dose-related increase in the release of
radiolabeled glycoprotein, but not of lysozyme. This secretagogue effect was selective for
high molecular weight glycoproteins of about 2–5× 10 6 daltons, and the median effective …
