[HTML][HTML] Leukotriene E4 activates peroxisome proliferator-activated receptor γ and induces prostaglandin D2 generation by human mast cells
S Paruchuri, Y Jiang, C Feng, SA Francis… - Journal of biological …, 2008 - ASBMB
Cysteinyl leukotrienes (cys-LTs) are potent inflammatory lipid mediators, of which
leukotriene (LT) E 4 is the most stable and abundant in vivo. Although only a weak agonist of
established G protein-coupled receptors (GPCRs) for cys-LTs, LTE 4 potentiates airway
hyper-responsiveness (AHR) by a cyclooxygenase (COX)-dependent mechanism and
induces bronchial eosinophilia. We now report that LTE 4 activates human mast cells (MCs)
by a pathway involving cooperation between an MK571-sensitive GPCR and peroxisome …
leukotriene (LT) E 4 is the most stable and abundant in vivo. Although only a weak agonist of
established G protein-coupled receptors (GPCRs) for cys-LTs, LTE 4 potentiates airway
hyper-responsiveness (AHR) by a cyclooxygenase (COX)-dependent mechanism and
induces bronchial eosinophilia. We now report that LTE 4 activates human mast cells (MCs)
by a pathway involving cooperation between an MK571-sensitive GPCR and peroxisome …
