Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment
M Pichavant, AS Charbonnier, S Taront… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Airway dendritic cells (DCs) are crucial for allergen-induced sensitization
and inflammation in allergic asthma. After allergen challenge, an increased number of DCs
is observed in airway epithelium from patients with allergy. OBJECTIVE: Because Der p 1, a
cysteine protease allergen from Dermatophagoides pteronyssinus, induces chemokine
production by bronchial epithelial cells (BECs), the purpose of this investigation was to
evaluate the capacity of BEC exposed to Der p 1 to recruit DCs. METHODS: Chemotactic …
and inflammation in allergic asthma. After allergen challenge, an increased number of DCs
is observed in airway epithelium from patients with allergy. OBJECTIVE: Because Der p 1, a
cysteine protease allergen from Dermatophagoides pteronyssinus, induces chemokine
production by bronchial epithelial cells (BECs), the purpose of this investigation was to
evaluate the capacity of BEC exposed to Der p 1 to recruit DCs. METHODS: Chemotactic …