Age-related changes in immune function: effect on airway inflammation
PJ Busse, SK Mathur - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Immunosenescence is defined as changes in the innate and adaptive immune response
associated with increased age. The clinical consequences of immunosenescence include
increased susceptibility to infection, malignancy and autoimmunity, decreased response to
vaccination, and impaired wound healing. However, there are several immune alterations
that might facilitate persistence of asthma into late adulthood or development of asthma after
the age of 50 to 60 years. Asthma in older patients is not uncommon, and this is a growing …
associated with increased age. The clinical consequences of immunosenescence include
increased susceptibility to infection, malignancy and autoimmunity, decreased response to
vaccination, and impaired wound healing. However, there are several immune alterations
that might facilitate persistence of asthma into late adulthood or development of asthma after
the age of 50 to 60 years. Asthma in older patients is not uncommon, and this is a growing …