Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia
K Asosingh, JD Hanson, G Cheng, MA Aronica… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Eosinophilic inflammation is closely related to angiogenesis in asthmatic
airway remodeling. In ovalbumin (OVA)–sensitized mice bone marrow–derived,
proangiogenic endothelial progenitor cells (EPCs) are rapidly recruited into the lungs after
OVA aerosol challenge and promptly followed by mobilization and recruitment of
eosinophils. OBJECTIVE: We hypothesized that bone marrow–derived EPCs initiate the
recruitment of eosinophils through expression of the eosinophil chemoattractant eotaxin-1 …
airway remodeling. In ovalbumin (OVA)–sensitized mice bone marrow–derived,
proangiogenic endothelial progenitor cells (EPCs) are rapidly recruited into the lungs after
OVA aerosol challenge and promptly followed by mobilization and recruitment of
eosinophils. OBJECTIVE: We hypothesized that bone marrow–derived EPCs initiate the
recruitment of eosinophils through expression of the eosinophil chemoattractant eotaxin-1 …