Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
D Xia, D Wang, SH Kim, H Katoh, RN DuBois - Nature medicine, 2012 - nature.com
D Xia, D Wang, SH Kim, H Katoh, RN DuBois
Nature medicine, 2012•nature.comAlthough aberrant DNA methylation is considered to be one of the key ways by which tumor-
suppressor and DNA-repair genes are silenced during tumor initiation and progression, the
mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we
show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair
genes through DNA methylation to promote tumor growth. These findings uncover a
previously unrecognized role for PGE2 in the promotion of tumor progression.
suppressor and DNA-repair genes are silenced during tumor initiation and progression, the
mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we
show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair
genes through DNA methylation to promote tumor growth. These findings uncover a
previously unrecognized role for PGE2 in the promotion of tumor progression.
Abstract
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE2 in the promotion of tumor progression.
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