Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent …
XL Yuan, L Chen, MX Li, P Dong, J Xue, J Wang… - Clinical …, 2010 - Elsevier
The transcription factor Foxp3 plays a key role in CD4+ CD25+ regulatory T (Treg) cell
function. A correlation has been shown between survival and the frequency of tumor-
infiltrating Foxp3-positive Treg cells in cancer patients. However, few studies have
characterized the regulation of Foxp3 expression and function in Treg cells, which are
known to comprise distinct subsets, with different roles in the complex tumor
microenvironment. Here, we show that significantly more Foxp3-positive Treg cells …
function. A correlation has been shown between survival and the frequency of tumor-
infiltrating Foxp3-positive Treg cells in cancer patients. However, few studies have
characterized the regulation of Foxp3 expression and function in Treg cells, which are
known to comprise distinct subsets, with different roles in the complex tumor
microenvironment. Here, we show that significantly more Foxp3-positive Treg cells …