Thyroid transcription factor-1 (TTF-1) is expressed in respiratory epithelial cells, where it
regulates the transcription of target genes expressed in a cell-selective manner. GATA-5 and-
6, members of the zinc finger family of transcription factors, are also expressed in various
cell types within in the developing lung. In the present work, GATA-6 mRNA was detected in
adult mouse lung, purified mouse type II epithelial cells, and differentiated mouse pulmonary
adenocarcinoma cells (MLE-15 cells), being co-expressed with TTF-1 mRNA. In order to test …