High proliferative activity of Reed Sternberg associated antigen Ki-1 positive cells in normal lymphoid tissue.

J Gerdes, R Schwarting, H Stein - Journal of clinical pathology, 1986 - jcp.bmj.com
J Gerdes, R Schwarting, H Stein
Journal of clinical pathology, 1986jcp.bmj.com
An improved immunoenzymatic double labelling method was developed, which
simultaneously shows the Ki-1 membrane antigen and the nuclear proliferation associated
antigen, defined by monoclonal antibody Ki-67. This new approach permits in situ
discrimination of cells that are proliferating or not with a particular membrane antigen. Most
Ki-1 positive cells in normal lymphoid tissue also express the Ki-67 nuclear antigen and thus
appear to be proliferating. As proliferating cells are more susceptible to malignant …
An improved immunoenzymatic double labelling method was developed, which simultaneously shows the Ki-1 membrane antigen and the nuclear proliferation associated antigen, defined by monoclonal antibody Ki-67. This new approach permits in situ discrimination of cells that are proliferating or not with a particular membrane antigen. Most Ki-1 positive cells in normal lymphoid tissue also express the Ki-67 nuclear antigen and thus appear to be proliferating. As proliferating cells are more susceptible to malignant transformation than quiescent cells, it is possible that the small number of normal Ki-1 positive cells might, none the less, cause a large proportion of all lymphomas in man.
jcp.bmj.com