[HTML][HTML] Autophagy and neurodegeneration

RA Frake, T Ricketts, FM Menzies… - The Journal of …, 2015 - Am Soc Clin Investig
RA Frake, T Ricketts, FM Menzies, DC Rubinsztein
The Journal of clinical investigation, 2015Am Soc Clin Investig
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a
powerful process for removing such proteins. In this Review, we consider how certain
neurodegenerative diseases may be associated with impaired autophagy and how this may
affect pathology. We also discuss how autophagy induction may be a plausible therapeutic
strategy for some conditions and review studies in various models that support this …
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.
The Journal of Clinical Investigation