[HTML][HTML] Constitutive Function of the Basic Helix-Loop-Helix/PAS Factor Arnt.: REGULATION OF TARGET PROMOTERS VIA THE E BOX MOTIF∗
C Antonsson, V Arulampalam, ML Whitelaw… - Journal of Biological …, 1995 - ASBMB
Arnt is a nuclear basic helix-loop-helix (bHLH) transcription factor that, contiguous with the
bHLH motif, contains a region of homology (PAS) with the Drosophila factors Per and Sim.
Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that
enables the dioxin-(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor
complex to recognize dioxin response elements of target promoters. In the absence of
dioxin, Arnt does not bind to this target sequence motif. The constitutive function of Arnt is …
bHLH motif, contains a region of homology (PAS) with the Drosophila factors Per and Sim.
Arnt dimerizes in a ligand-dependent manner with the bHLH dioxin receptor, a process that
enables the dioxin-(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)-activated Arnt-dioxin receptor
complex to recognize dioxin response elements of target promoters. In the absence of
dioxin, Arnt does not bind to this target sequence motif. The constitutive function of Arnt is …