Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice
JD Joo, M Kim, VD D'Agati, HT Lee - Journal of the American …, 2006 - journals.lww.com
Acute as well as delayed ischemic preconditioning (IPC) provides protection against cardiac
and neuronal ischemia reperfusion (IR) injury. This study determined whether delayed
preconditioning occurs in the kidney and further elucidated the mechanisms of renal IPC in
mice. Mice were subjected to IPC (four cycles of 5 min of ischemia and reperfusion) and then
to 30 min of renal ischemia either 15 min (acute IPC) or 24 h (delayed IPC) later. Both acute
and delayed renal IPC provided powerful protection against renal IR injury. Inhibition of Akt …
and neuronal ischemia reperfusion (IR) injury. This study determined whether delayed
preconditioning occurs in the kidney and further elucidated the mechanisms of renal IPC in
mice. Mice were subjected to IPC (four cycles of 5 min of ischemia and reperfusion) and then
to 30 min of renal ischemia either 15 min (acute IPC) or 24 h (delayed IPC) later. Both acute
and delayed renal IPC provided powerful protection against renal IR injury. Inhibition of Akt …