[HTML][HTML] Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton

E Werner, AP Kowalczyk, V Faundez - Journal of biological chemistry, 2006 - ASBMB
Tumor endothelial marker 8 (TEM8) is induced in tumor-associated vasculature and acts as
a receptor for Protective Antigen (PA), the cell-binding component of the anthrax toxin
determinant for toxin entrance into cells. However, the normal function for TEM8 remains
unknown. We show that TEM8 functions as an adhesion molecule mediating cell spreading
on immobilized PA and collagen I. The mechanism for TEM8 interaction with collagen I was
cell type-specific, because binding to collagen I was abrogated by β1 integrin function …