A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

K Hargreaves, R Dubner, F Brown, C Flores, J Joris - Pain, 1988 - Elsevier
A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals
is described. The testing paradigm uses an automated detection of the behavioral end-point;
repeated testing does not contribute to the development of the observed hyperalgesia.
Carrageenan-induced inflammation resulted in significantly shorter paw withdrawal
latencies as compared to saline-treated paws and these latency changes corresponded to a
decreased thermal nociceptive threshold. Both the thermal method and the Randall-Selitto …