EPA and DHA are not biologically equivalent; however, their individual activity on B cells is
unknown. We previously reported fish oil enhanced murine B-cell activity in obesity. To
distinguish between the effects of EPA and DHA, we studied the ethyl esters of EPA and
DHA on murine B-cell function as a function of time. We first demonstrate that EPA and DHA
maintained the obese phenotype, with no improvements in fat mass, adipose inflammatory
cytokines, fasting insulin, or glucose clearance. We then tested the hypothesis that EPA and …