[HTML][HTML] Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis
We performed untargeted metabolomics in plasma of B6 mice with experimental
autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered
metabolic pathway (s). Of 324 metabolites measured, 100 metabolites that mapped to
various pathways (mainly lipids) linked to mitochondrial function, inflammation, and
membrane stability were observed to be significantly altered between EAE and control (p<
0.05, false discovery rate< 0.10). Bioinformatics analysis revealed six metabolic pathways …
autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered
metabolic pathway (s). Of 324 metabolites measured, 100 metabolites that mapped to
various pathways (mainly lipids) linked to mitochondrial function, inflammation, and
membrane stability were observed to be significantly altered between EAE and control (p<
0.05, false discovery rate< 0.10). Bioinformatics analysis revealed six metabolic pathways …