[HTML][HTML] The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering

A Ariel, PL Li, W Wang, WX Tang, G Fredman… - Journal of Biological …, 2005 - ASBMB
Docosahexaenoic acid, a major ω-3 fatty acid in human brain, synapses, retina, and other
neural tissues, displays beneficial actions in neuronal development, cancer, and
inflammatory diseases by mechanisms that remain to be elucidated. In this study we found,
using lipid mediator informatics employing liquid chromatography-tandem mass
spectrometry, that (10, 17S)-docosatriene/neuroprotectin D1, now termed protectin D1
(PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood …