[HTML][HTML] Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity
S Ahmad, AJ Ytterberg, M Thulasingam… - Journal of Biological …, 2016 - ASBMB
Leukotriene C 4 synthase (LTC4S) catalyzes the formation of the proinflammatory lipid
mediator leukotriene C 4 (LTC 4). LTC 4 is the parent molecule of the cysteinyl leukotrienes,
which are recognized for their pathogenic role in asthma and allergic diseases. Cellular
LTC4S activity is suppressed by PKC-mediated phosphorylation, and recently a downstream
p70S6k was shown to play an important role in this process. Here, we identified Ser 36 as
the major p70S6k phosphorylation site, along with a low frequency site at Thr 40, using an in …
mediator leukotriene C 4 (LTC 4). LTC 4 is the parent molecule of the cysteinyl leukotrienes,
which are recognized for their pathogenic role in asthma and allergic diseases. Cellular
LTC4S activity is suppressed by PKC-mediated phosphorylation, and recently a downstream
p70S6k was shown to play an important role in this process. Here, we identified Ser 36 as
the major p70S6k phosphorylation site, along with a low frequency site at Thr 40, using an in …