[HTML][HTML] Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase
M Luo, SM Jones, N Flamand, DM Aronoff… - Journal of Biological …, 2005 - ASBMB
The enzyme 5-lipoxygenase initiates the synthesis of leukotrienes from arachidonic acid.
Protein kinase A phosphorylates 5-lipoxygenase on Ser 523, and this reduces its activity.
We report here that phosphorylation of Ser 523 also shifts the subcellular distribution of 5-
lipoxygenase from the nucleus to the cytoplasm. Phosphorylation and redistribution of 5-
lipoxygenase could be produced by overexpression of the protein kinase A catalytic subunit
α, by pharmacological activators of protein kinase A, and by prostaglandin E 2. Mimicking …
Protein kinase A phosphorylates 5-lipoxygenase on Ser 523, and this reduces its activity.
We report here that phosphorylation of Ser 523 also shifts the subcellular distribution of 5-
lipoxygenase from the nucleus to the cytoplasm. Phosphorylation and redistribution of 5-
lipoxygenase could be produced by overexpression of the protein kinase A catalytic subunit
α, by pharmacological activators of protein kinase A, and by prostaglandin E 2. Mimicking …