Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice
RY Cao, MA Adams, AJ Habenicht, CD Funk - Prostaglandins & other lipid …, 2007 - Elsevier
Genetic association studies and pathological analysis of cardiovascular disease specimens
implicate a role for the 5-lipoxygenase (5-LO)/leukotriene (LT) pathway in human
cardiovascular disease. Previously, we had detected a role for this pathway in the incidence
and severity of hyperlipidemic, cholate-containing, diet-induced aortic aneurysm in mice.
The goal of the present study was to assess the importance of the 5-LO/LT pathway in
angiotensin II (Ang II)-induced murine abdominal aortic aneurysm (AAA) formation. Mice …
implicate a role for the 5-lipoxygenase (5-LO)/leukotriene (LT) pathway in human
cardiovascular disease. Previously, we had detected a role for this pathway in the incidence
and severity of hyperlipidemic, cholate-containing, diet-induced aortic aneurysm in mice.
The goal of the present study was to assess the importance of the 5-LO/LT pathway in
angiotensin II (Ang II)-induced murine abdominal aortic aneurysm (AAA) formation. Mice …
