[HTML][HTML] Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53
TA Taha, W Osta, L Kozhaya, J Bielawski… - Journal of Biological …, 2004 - ASBMB
Sphingosine kinase 1 (SK1), a key enzyme in sphingosine 1-phosphate (S1P) synthesis,
regulates various aspects of cell behavior, including cell survival and proliferation. DNA
damaging anti-neoplastic agents have been shown to induce p53, ceramide levels, and
apoptosis; however, the effects of anti-neoplastic agents on SK have not been assessed. In
this study, we investigated the effects of a DNA damaging agent, actinomycin D (Act D), on
the function of sphingosine kinase (SK1). Act D caused a reduction in the protein levels of …
regulates various aspects of cell behavior, including cell survival and proliferation. DNA
damaging anti-neoplastic agents have been shown to induce p53, ceramide levels, and
apoptosis; however, the effects of anti-neoplastic agents on SK have not been assessed. In
this study, we investigated the effects of a DNA damaging agent, actinomycin D (Act D), on
the function of sphingosine kinase (SK1). Act D caused a reduction in the protein levels of …