Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and …
NA Crivello, IH Rosenberg, GE Dallal… - Neurochemistry …, 2005 - Elsevier
Previous studies show the enrichment of mammalian brain with neutral sphingomyelin-
specific phospholipase C (ceramide-phosphocholine phosphodiesterase, EC 3.1. 4.12; N-
Sase), a key enzyme of sphingolipid metabolism and sphingolipid-induced signaling.
OBJECTIVE:: The objective of this study was to evaluate the membrane-associated and
cytosolic N-Sase activities in the brain regions associated with behavior (striatum,
hippocampus, and frontal cortex). RESULTS:: Results showed higher membrane-associated …
specific phospholipase C (ceramide-phosphocholine phosphodiesterase, EC 3.1. 4.12; N-
Sase), a key enzyme of sphingolipid metabolism and sphingolipid-induced signaling.
OBJECTIVE:: The objective of this study was to evaluate the membrane-associated and
cytosolic N-Sase activities in the brain regions associated with behavior (striatum,
hippocampus, and frontal cortex). RESULTS:: Results showed higher membrane-associated …