[HTML][HTML] BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration
DH Zhu, J Wu, C Spee, SJ Ryan, DR Hinton - Journal of biological …, 2009 - ASBMB
The retinal pigment epithelium is a primary site of pathology in age-related macular
degeneration. Oxidative stress and senescence are both thought to be important mediators
of macular degeneration pathogenesis. We demonstrate here that bone morphogenetic
protein-4 is highly expressed in the retinal pigment epithelium and adjacent extracellular
matrix of patients with dry age-related macular degeneration. In vitro studies revealed that
sublethal oxidative stress increased bone morphogenetic protein-4 expression in retinal …
degeneration. Oxidative stress and senescence are both thought to be important mediators
of macular degeneration pathogenesis. We demonstrate here that bone morphogenetic
protein-4 is highly expressed in the retinal pigment epithelium and adjacent extracellular
matrix of patients with dry age-related macular degeneration. In vitro studies revealed that
sublethal oxidative stress increased bone morphogenetic protein-4 expression in retinal …