Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles
ER Wood, L Kuyper, KG Petrov, RN Hunter III… - Bioorganic & medicinal …, 2004 - Elsevier
ER Wood, L Kuyper, KG Petrov, RN Hunter III, PA Harris, K Lackey
Bioorganic & medicinal chemistry letters, 2004•ElsevierThe discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-
hydroxy-5-(2′-methoxyphenyl)-benzylidene)-5-bromo-1, 3-dihydro-pyrrolo [2, 3-b] pyridin-2-
one, 3-[(1-methyl-1H-indol-3-yl) methylene]-1, 3-dihydro-2H-pyrrolo [3, 2-b]-pyridin-2-one as
potent TrkA inhibitors are discussed.
hydroxy-5-(2′-methoxyphenyl)-benzylidene)-5-bromo-1, 3-dihydro-pyrrolo [2, 3-b] pyridin-2-
one, 3-[(1-methyl-1H-indol-3-yl) methylene]-1, 3-dihydro-2H-pyrrolo [3, 2-b]-pyridin-2-one as
potent TrkA inhibitors are discussed.
The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2′-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.
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