[HTML][HTML] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by …

A Tanimoto, Y Murata, KY Wang, M Tsutsui… - Journal of biological …, 2008 - ASBMB
The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF)
is expressed in inflammatory and atherosclerotic lesions. GM-CSF is known to enhance
monocytic expression of monocyte chemoattractant protein-1 (MCP-1). However, the
molecular mechanism (s) by which GM-CSF up-regulates the MCP-1 expression remains to
be clarified. Thus, in this study, we examined our hypothesis that GM-CSF up-regulates the
MCP-1 expression via Jak2-Stat5 signaling pathway. In human monocytic cell line U937 …