Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model

H McGowan, J Schuijers, B Grills, S McDonald… - 2014 - opal.latrobe.edu.au
H McGowan, J Schuijers, B Grills, S McDonald, A McDonald
2014opal.latrobe.edu.au
Objectives: Previous studies have shown galanin (GAL) injections onto mouse calvaria
increased bone thickness and osteoblast number. This study investigated the effects of the
GAL receptor agonist galnon on bone loss using the ovariectomised (OVX) rat model.
Methods: OVX rats were treated with either vehicle or galnon for 6 weeks via mini-osmotic
pumps. Plasma osteocalcin concentrations, osseous cell gene expression, morphological
and biomechanical properties of the skeleton were compared between the two groups …
Objectives
Previous studies have shown galanin (GAL) injections onto mouse calvaria increased bone thickness and osteoblast number. This study investigated the effects of the GAL receptor agonist galnon on bone loss using the ovariectomised (OVX) rat model.
Methods
OVX rats were treated with either vehicle or galnon for 6 weeks via mini-osmotic pumps. Plasma osteocalcin concentrations, osseous cell gene expression, morphological and biomechanical properties of the skeleton were compared between the two groups.
Results
Treatment with galnon increased RANKL:OPG gene ratio (p
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