FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB
YN Ohnishi, YH Ohnishi, M Hokama, H Nomaru… - Biological …, 2011 - Elsevier
BACKGROUND: Molecular mechanisms underlying stress tolerance and vulnerability are
incompletely understood. The fosB gene is an attractive candidate for regulating stress
responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates
after repeated stress or antidepressant treatments. On the other hand, FosB, the other
alternative splice product of the fosB gene, expresses more transiently than ΔFosB but
exerts higher transcriptional activity. However, the functional differences of these two fosB …
incompletely understood. The fosB gene is an attractive candidate for regulating stress
responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates
after repeated stress or antidepressant treatments. On the other hand, FosB, the other
alternative splice product of the fosB gene, expresses more transiently than ΔFosB but
exerts higher transcriptional activity. However, the functional differences of these two fosB …