Nectins and nectin-like molecules in development and disease
K Mandai, Y Rikitake, M Mori, Y Takai - Current topics in developmental …, 2015 - Elsevier
Nectins and nectin-like molecules (Necls)/Cadms are Ca 2+-independent immunoglobulin
superfamily cell adhesion molecules, expressed in most cell types. Nectins mediate not only
homotypic but also heterotypic cell-cell adhesion, in contrast to classic cadherins which
participate only in homophilic adhesion. Nectins and Necls function in organogenesis of the
eye, inner ear, tooth, and cerebral cortex and in a variety of developmental processes
including spermatogenesis, axon guidance, synapse formation, and myelination. They are …
superfamily cell adhesion molecules, expressed in most cell types. Nectins mediate not only
homotypic but also heterotypic cell-cell adhesion, in contrast to classic cadherins which
participate only in homophilic adhesion. Nectins and Necls function in organogenesis of the
eye, inner ear, tooth, and cerebral cortex and in a variety of developmental processes
including spermatogenesis, axon guidance, synapse formation, and myelination. They are …